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Atypical lipomatous tumor

MedGen UID:
266102
Concept ID:
C1266129
Neoplastic Process
Synonyms: Atypical Lipoma; Atypical Lipomas; Lipoma, Atypical; Lipomas, Atypical
SNOMED CT: Atypical lipoma (116063003); Atypical lipomatous tumor (116063003)
 
Monarch Initiative: MONDO:0006097

Definition

A locally aggressive mesenchymal neoplasm composed either entirely or partly of an adipocytic proliferation showing at least focal nuclear atypia in both adipocytes and stromal cells. ""Atypical lipomatous tumor"" and ""well-differentiated liposarcoma"" are synonyms describing lesions that are morphologically and genetically identical. Amplification of MDM2 and/or CDK4 is almost always present. (WHO 2020) [from NCI]

Professional guidelines

PubMed

Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Rizer M, Singer AD, Edgar M, Jose J, Subhawong TK
Skeletal Radiol 2016 Sep;45(9):1193-204. Epub 2016 May 21 doi: 10.1007/s00256-016-2409-4. PMID: 27209201

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Crim J, Layfield LJ
Skeletal Radiol 2023 Mar;52(3):379-392. Epub 2022 Jun 29 doi: 10.1007/s00256-022-04099-1. PMID: 35767018
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Kang JY, Kim HJ, Wojno TH, Yeung AM, Mendoza PR, Grossniklaus HE
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3S):S134-S140. doi: 10.1097/IOP.0000000000001804. PMID: 32991496
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315

Diagnosis

Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Thway K
Semin Diagn Pathol 2019 Mar;36(2):112-121. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.006. PMID: 30852045
Briski LM, Jorns JM
Arch Pathol Lab Med 2018 Feb;142(2):268-274. doi: 10.5858/arpa.2016-0380-RSR2. PMID: 29372852

Therapy

Gitto S, Interlenghi M, Cuocolo R, Salvatore C, Giannetta V, Badalyan J, Gallazzi E, Spinelli MS, Gallazzi M, Serpi F, Messina C, Albano D, Annovazzi A, Anelli V, Baldi J, Aliprandi A, Armiraglio E, Parafioriti A, Daolio PA, Luzzati A, Biagini R, Castiglioni I, Sconfienza LM
Radiol Med 2023 Aug;128(8):989-998. Epub 2023 Jun 19 doi: 10.1007/s11547-023-01657-y. PMID: 37335422Free PMC Article
Schöffski P
Oncol Res Treat 2022;45(9):525-543. Epub 2022 May 24 doi: 10.1159/000524939. PMID: 35609512
Mashima E, Sawada Y, Nakamura M
Int J Mol Sci 2021 Jan 20;22(3) doi: 10.3390/ijms22030994. PMID: 33498189Free PMC Article
Manji GA, Schwartz GK
J Oncol Pract 2016 Mar;12(3):221-7. doi: 10.1200/JOP.2015.009860. PMID: 26962163
Abbas Manji G, Singer S, Koff A, Schwartz GK
Am Soc Clin Oncol Educ Book 2015:213-8. doi: 10.14694/EdBook_AM.2015.35.213. PMID: 25993159

Prognosis

Nishio J, Nakayama S, Chijiiwa Y, Aoki M
Anticancer Res 2023 Oct;43(10):4295-4301. doi: 10.21873/anticanres.16624. PMID: 37772567
Kawai T, Nakashima H, Washimi K, Yokose T, Matsuo T, Nakayama M, Shinohara N, Kuroda H, Ishida K, Akiba J, Ishikawa M, Urabe S, Shiraishi J, Shiraishi T, Sakamoto A, Matsukuma S
Hum Pathol 2023 Jun;136:105-113. Epub 2023 Apr 5 doi: 10.1016/j.humpath.2023.03.009. PMID: 37023867
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Creytens D
Virchows Arch 2020 Jan;476(1):29-39. Epub 2019 Sep 9 doi: 10.1007/s00428-019-02652-3. PMID: 31501988
Coindre JM, Pédeutour F, Aurias A
Virchows Arch 2010 Feb;456(2):167-79. Epub 2009 Aug 18 doi: 10.1007/s00428-009-0815-x. PMID: 19688222

Clinical prediction guides

Kilpatrick SE
Hum Pathol 2024 May;147:82-91. Epub 2023 Dec 21 doi: 10.1016/j.humpath.2023.12.005. PMID: 38135062
Sugiyama K, Washimi K, Sato S, Hiruma T, Sakai M, Okubo Y, Miyagi Y, Yokose T
Diagn Cytopathol 2022 Mar;50(3):112-122. Epub 2022 Jan 4 doi: 10.1002/dc.24928. PMID: 34984861Free PMC Article
Graf A, Yang K, King D, Dzwierzynski W, Sanger J, Hettinger P
Hand (N Y) 2019 May;14(3):333-338. Epub 2017 Oct 23 doi: 10.1177/1558944717735946. PMID: 29058949Free PMC Article
Schaefer IM, Hornick JL
Adv Anat Pathol 2018 Nov;25(6):400-412. doi: 10.1097/PAP.0000000000000204. PMID: 30134255Free PMC Article
Al Hmada Y, Schaefer IM, Fletcher CDM
Am J Surg Pathol 2018 Jul;42(7):951-957. doi: 10.1097/PAS.0000000000001061. PMID: 29629919Free PMC Article

Recent systematic reviews

Haidey J, Low G, Wilson MP
Skeletal Radiol 2023 Jun;52(6):1089-1100. Epub 2022 Nov 16 doi: 10.1007/s00256-022-04232-0. PMID: 36385583
Fourman MS, van Eck CF, Weiss KR, Goodman MA, McGough RL
Am J Clin Oncol 2019 May;42(5):487-492. doi: 10.1097/COC.0000000000000540. PMID: 30932920
Kandel RA, Yao X, Dickson BC, Ghert M, Popovic S, Purgina BM, Verma S, Werier J
Cancer Treat Rev 2018 May;66:74-81. Epub 2018 Apr 22 doi: 10.1016/j.ctrv.2018.04.005. PMID: 29709714

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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